Endep
This medicine is indicated for depressive disorders utilized to alleviate persistent neuropathic pain for patients requiring structured therapeutic support.
- Category
- Antidepressants
- Active ingredient
- Amitriptyline
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 10 · 25 · 50 · 75mg
You will receive a quality generic equivalent, depending on stock.
Prescription rules on Endep vary by country.
Endep details
- Conditions
- Major Depressive Disorder · Neuropathic Pain
- Alternative names
- Tryptizol
- Therapeutic class
- Tricyclic Antidepressant
- Pharmacological class
- TCA
- Known off-label uses
- migraine prophylaxis
- Contraindications
- hypersensitivity to amitriptyline; recent myocardial infarction; arrhythmia
- Minor side effects
- dry mouth; drowsiness; dizziness
- Moderate side effects
- blurred vision; urinary retention; constipation
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Originator
- AstraZeneca
- Onset Time
- 2–4 weeks
- Duration
- 24 hours
- Storage instructions
- Store at room temperature in a cool, dry place away from direct sunlight.
- Drug interactions
- Alcohol; MAO inhibitors
- Age restrictions
- Not recommended for children and adolescents.
Precautions and warnings
may impair ability to drive or operate machinery; use with caution in elderly patients
Serious side effects
suicidal ideation, requires immediate medical attention; cardiac arrhythmia, requires immediate medical attention
Patient summary
This medicine is indicated for depressive disorders utilized to alleviate persistent neuropathic pain for patients requiring structured therapeutic support.
Mechanism of action
Amitriptyline acts by inhibiting the reuptake of neurotransmitters, specifically serotonin and norepinephrine, within the central nervous system. This enhances synaptic concentrations of these chemicals, helping to stabilize mood and modulate pain signaling pathways effectively.
Pregnancy and breastfeeding
Pregnancy: Use only if clearly necessary after medical assessment. Breastfeeding: Small amounts pass into milk; consult your doctor for guidance.
What you will receive
Endep is the originator brand name, made by AstraZeneca. We use it here to identify the medicine only; we are not affiliated with AstraZeneca and do not ship the original Endep.
- You receive a generic equivalent: the same active ingredient (Amitriptyline) at the same dose, mostly recognised Indian branded generics from vetted manufacturers.
- The exact brand supplied depends on what is in stock at the dispatching warehouse.
- A regulated generic matches the original ingredient for ingredient by legal standard.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Endep
Endep contains the active ingredient Amitriptyline, used to assist with the management of Major Depressive Disorder and Neuropathic Pain. The same chemical is also sold as Tryptizol. It is supplied as a tablet in strengths of 10, 25, 50, and 75mg.
Endep availability in Asia
Endep is registered across 14 markets including Indonesia, Taiwan and South Korea, with availability also in Japan, the UAE and Singapore. Generic Amitriptyline often provides a more affordable option for the original brand, helping expats and those living in remote locations maintain their health regimen. This medication is best used under a doctor’s care to ensure that treatment remains monitored and appropriate for individual needs.