Istamet
Formulated to target type 2 diabetes mellitus to support glycemic control.
- Category
- Diabetes Management
- Active ingredients
- Sitagliptin · Metformin
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 50/1000mg
Istamet details
- Condition
- Type 2 Diabetes Mellitus
- Alternative names
- Janumet
- Therapeutic class
- Dipeptidyl Peptidase-4 (DPP-4) Inhibitor; Biguanide Antidiabetic
- Pharmacological class
- DPP-4 Inhibitor; Biguanide
- Minor side effects
- nausea; diarrhoea; headache
- Moderate side effects
- upper respiratory tract infection; nasopharyngitis
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Patient summary
- formulated to target type 2 diabetes mellitus to support glycemic control.
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Merck Sharp & Dohme
- Onset Time
- 1–2 hours
- Duration
- 12–24 hours
- Storage instructions
- Store below 25°C, away from sunlight and moisture.
- Drug interactions
- Alcohol; Iodinated contrast media
- Age restrictions
- Not indicated for use in children or adolescents.
Contraindications
hypersensitivity to sitagliptin; hypersensitivity to metformin; severe renal impairment; diabetic ketoacidosis; severe hepatic impairment
Precautions and warnings
monitor renal function regularly; risk of lactic acidosis; discontinue if symptoms of pancreatitis occur
Serious side effects
pancreatitis, requires immediate medical attention; lactic acidosis, requires immediate medical attention; anaphylaxis, requires immediate medical attention
Mechanism of action
This medicine combines two active agents that work by increasing incretin levels to stimulate insulin release after meals and by reducing glucose production in the liver, effectively lowering blood sugar levels.
Pregnancy and breastfeeding
Pregnancy: should be avoided unless clearly necessary. Breastfeeding: not recommended as components may pass into breast milk.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Istamet
Istamet combines sitagliptin and metformin within a single tablet to help manage Type 2 Diabetes Mellitus. Also marketed internationally as Janumet, this dual-action medication manufactured by Merck Sharp & Dohme is available in strengths including 50/1000mg. Patients relying on this combination for glycaemic control often select these branded oral treatments for their consistent formulation and reliability.
Buying Istamet online
Istamet is registered across 13 markets including Taiwan, South Korea and Japan, with availability also in the UAE, Singapore and Hong Kong. For many expats and those living far from a well-stocked pharmacy, ordering this medication online provides a consistent way to maintain regular supplies. While branded versions remain common, many users also consider generic sitagliptin and metformin, much of it made in India, as a more affordable option for long-term health management.