Glucovance
Designed to manage type 2 diabetes mellitus to support insulin sensitivity and blood glucose regulation.
- Category
- Diabetes Management
- Active ingredients
- Metformin · Glibenclamide
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 400/2.50 · 500/5mg
Glucovance details
- Condition
- Type 2 Diabetes Mellitus
- Therapeutic class
- Biguanide Antidiabetic; Sulfonylurea
- Pharmacological class
- Biguanide; Sulfonylurea
- Contraindications
- hypersensitivity; severe renal impairment; diabetic ketoacidosis; diabetic coma
- Precautions and warnings
- monitor kidney function regularly; risk of lactic acidosis
- Minor side effects
- nausea; diarrhoea; abdominal pain
- Moderate side effects
- hypoglycaemia; headache; dizziness
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Merck Serono
- Onset Time
- 1–2 hours
- Duration
- 12–24 hours
- Storage instructions
- Store in a cool, dry place away from direct light and moisture.
- Drug interactions
- Alcohol; Cimetidine
- Age restrictions
- Not indicated for use in children.
Serious side effects
lactic acidosis, requires immediate medical attention; anaphylaxis, requires immediate medical attention
Patient summary
Designed to manage type 2 diabetes mellitus to support insulin sensitivity and blood glucose regulation.
Mechanism of action
This medicine combines two active agents: one that lowers liver glucose production and intestinal absorption, and another that stimulates the pancreas to release more insulin. Together, they help maintain balanced blood sugar levels in patients who have not achieved adequate control through diet or exercise alone.
Pregnancy and breastfeeding
Pregnancy: Use is generally avoided; insulin is preferred for blood glucose control. Breastfeeding: Not recommended as safety data is limited.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Glucovance
Glucovance combines Metformin and Glibenclamide to assist in the treatment of Type 2 Diabetes Mellitus. Produced by Merck Serono, this medication comes as a tablet in strengths of 400/2.50mg and 500/5mg. It provides an established option for individuals requiring dual-agent support to help manage blood glucose levels effectively.
Buying Glucovance online
Glucovance is registered across 14 markets, including Hong Kong, Thailand and Malaysia, with availability also in the Philippines, Indonesia and Taiwan. As one of the most ordered treatments for glycaemic control, it helps support patients across the region. Generic versions of Metformin and Glibenclamide, largely produced in India, provide a significantly more affordable option than the original brand for expats and travelers who find themselves far from reliable local health sources.