Zestoretic
Lisinopril · Hydrochlorothiazide
Formulated to alleviate high blood pressure and developed to mitigate strain on the cardiovascular system.
- Category
- Heart & Blood Pressure
- Active ingredients
- Lisinopril · Hydrochlorothiazide
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Tablet
- Strengths
- 5/12.5g/mg
Zestoretic details
- Condition
- Hypertension
- Therapeutic class
- ACE Inhibitor; Thiazide Diuretic
- Pharmacological class
- ACE Inhibitor; Thiazide Diuretic
- Minor side effects
- dizziness; headache; fatigue; dry cough
- Moderate side effects
- hypotension; diarrhoea; nausea; rash
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- AstraZeneca
- Onset Time
- 1–2 hours
- Duration
- 24 hours
- Storage instructions
- Store in original packaging.
- Drug interactions
- NSAIDs; Potassium supplements; Lithium
- Age restrictions
- Not recommended for children.
- Pregnancy and breastfeeding
- Pregnancy: Must not be used. Breastfeeding: Not recommended.
Contraindications
history of angioedema; renal artery stenosis; pregnancy; anuria; severe renal impairment
Precautions and warnings
monitor potassium levels; avoid salt substitutes containing potassium; maintain adequate hydration; may cause hypotension in volume-depleted patients
Serious side effects
angioedema, requires immediate medical attention; agranulocytosis, requires immediate medical attention; acute renal failure, requires immediate medical attention
Patient summary
Formulated to alleviate high blood pressure and developed to mitigate strain on the cardiovascular system.
Mechanism of action
This combination therapy works through two pathways: halting the production of angiotensin II to relax blood vessels, and promoting the excretion of excess water and sodium through the kidneys to reduce fluid volume and lower pressure.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Zestoretic
Zestoretic is a widely recognised therapy containing lisinopril and hydrochlorothiazide, used to assist in the management of hypertension. Developed by AstraZeneca, this medication helps patients control blood pressure levels through its combined action. It is supplied as a tablet in a 5/12.5g/mg strength, providing a standard option for daily use.
Buying Zestoretic online
Zestoretic is registered across 14 markets including Malaysia, the Philippines and Indonesia, with availability also in Taiwan, South Korea and Japan. For expats and people living across Asia, ordering these supplies online provides an accessible way to maintain continuity of care without the need to locate a well-stocked pharmacy. It is one of the most ordered medications for blood pressure management across the region.