Sinequan
This medication is indicated to address depression and anxiety-related symptoms and intended to support mood stabilization in patients.
- Category
- Antidepressants
- Active ingredient
- Doxepin
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Capsule, hard
- Strengths
- 10 · 25 · 75mg
Sinequan details
- Conditions
- Major Depressive Disorder · Anxiety · Anxiety Disorder
- Therapeutic class
- Tricyclic Antidepressant
- Pharmacological class
- Tricyclic Antidepressant (TCA)
- Known off-label uses
- insomnia
- Contraindications
- urinary retention; narrow-angle glaucoma; concurrent use of MAO inhibitors
- Precautions and warnings
- may cause drowsiness; caution in prostatic hypertrophy
- Minor side effects
- dry mouth; blurred vision; constipation; drowsiness
- Moderate side effects
- tachycardia; orthostatic hypotension
- Dosage forms
- Capsule, hard
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Pfizer
- Onset Time
- 2–3 weeks
- Duration
- long-term
- Storage instructions
- Store at room temperature in a dry place.
- Drug interactions
- Alcohol; Antihistamines; MAO inhibitors
- Age restrictions
- Use with caution in elderly patients.
- Pregnancy and breastfeeding
- Pregnancy: consult a doctor. Breastfeeding: not recommended.
Serious side effects
suicidal ideation, requires immediate medical attention; cardiac arrhythmia, requires immediate medical attention
Patient summary
This medication is indicated to address depression and anxiety-related symptoms and intended to support mood stabilization in patients.
Mechanism of action
Doxepin acts by inhibiting the reuptake of both serotonin and norepinephrine in the central nervous system synapses, thereby increasing their concentration and improving mood.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Sinequan
Sinequan contains Doxepin, a medication for treating Major Depressive Disorder, Anxiety and Anxiety Disorder. Pfizer provides this preparation as a tablet in strengths of 10, 25 and 75mg. The formulation is intended to support those managing mental health concerns and requires use under a doctor’s care for the best outcomes.
Sinequan availability in Asia
Sinequan is registered across 13 markets including the Philippines, Indonesia and Taiwan, with wider availability in South Korea, the UAE and Singapore. Generic Doxepin, much of it made in India, is often available as a more affordable alternative to the original brand. For expats and people residing in areas with limited medical infrastructure, identifying these options supports consistent health management. Patients should ensure they use this medication under the guidance and supervision of their doctor.