Grisactin
This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.
- Category
- Antifungals
- Active ingredient
- Griseofulvin
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Tablet
- Strengths
- 250mg
Grisactin details
- Condition
- Dermatophytosis
- Alternative names
- Fulcin
- Therapeutic class
- Antifungal
- Pharmacological class
- Benzofuran
- Minor side effects
- nausea; diarrhoea; headache; fatigue
- Moderate side effects
- rash; urticaria
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Wyeth
- Onset Time
- 1–2 weeks
- Duration
- 4–8 weeks
- Storage instructions
- Store in a cool, dry place away from direct light.
- Drug interactions
- Alcohol; Warfarin; Oral contraceptives; Ciclosporin
- Age restrictions
- Use with caution in children.
Contraindications
hypersensitivity to griseofulvin; porphyria; severe hepatic impairment; systemic lupus erythematosus
Precautions and warnings
avoid pregnancy during treatment and for one month after; caution in patients with liver disease; regular monitoring of blood counts and liver function recommended
Serious side effects
hepatotoxicity, requires immediate medical attention; leukopenia, requires immediate medical attention; photosensitivity, requires immediate medical attention
Patient summary
This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.
Mechanism of action
Griseofulvin works by depositing itself within keratin precursor cells, making them resistant to fungal invasion. It inhibits fungal cell mitosis by disrupting the mitotic spindle, effectively stopping the growth and replication of dermatophyte fungi such as Trichophyton, Microsporum, and Epidermophyton species.
Pregnancy and breastfeeding
Pregnancy: strictly contraindicated. Breastfeeding: not recommended due to lack of safety data.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Grisactin
Grisactin is a recognised brand of griseofulvin, an active ingredient used in the management of dermatophytosis. The medication is also sold under names such as Fulcin, offered in a tablet form at a strength of 250mg. Originally produced by Wyeth, these tablets remain a consistent option for patients seeking specific treatment for their fungal conditions.
Buying Grisactin online
Grisactin is registered across 13 markets, including Taiwan, South Korea and Japan, with availability also in the UAE, Singapore and Hong Kong. Generic griseofulvin, much of it produced in India, is far more affordable than the original brand. This allows for easier access for expats and people living in areas far from a well stocked supply, remaining one of the most ordered medications for these dermatological needs across the region.