Tofranil
This medication is developed to address symptoms of depression and utilized for children with nocturnal enuresis.
- Category
- Antidepressants
- Active ingredient
- Imipramine
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Tablet
- Strengths
- 25 · 50 · 75mg
Tofranil details
- Conditions
- Major Depressive Disorder · Enuresis · Nocturnal Enuresis
- Therapeutic class
- Tricyclic Antidepressant
- Pharmacological class
- Tricyclic Antidepressant (TCA)
- Precautions and warnings
- may impair driving; regular blood pressure monitoring
- Minor side effects
- dry mouth; blurred vision; constipation; dizziness
- Moderate side effects
- tachycardia; urinary retention; confusion
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Novartis
- Onset Time
- 2–4 weeks
- Duration
- long-term
- Storage instructions
- Store in a dry place.
- Drug interactions
- Alcohol; MAO inhibitors; Antihypertensives
- Age restrictions
- Used in children for enuresis.
- Pregnancy and breastfeeding
- Pregnancy: use only if essential. Breastfeeding: contraindicated.
Contraindications
recent myocardial infarction; concurrent use of MAO inhibitors; prostatic hypertrophy
Serious side effects
cardiac arrhythmia, requires immediate medical attention; seizures, requires immediate medical attention
Patient summary
This medication is developed to address symptoms of depression and utilized for children with nocturnal enuresis.
Mechanism of action
Imipramine blocks the neuronal reuptake of norepinephrine and serotonin. This increases their availability in the synaptic cleft, exerting an antidepressant effect, while its anticholinergic effect helps manage bedwetting.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Tofranil
Tofranil is a well-established medication containing imipramine, an ingredient primarily used to manage Major Depressive Disorder, Enuresis and Nocturnal Enuresis. Manufactured by Novartis, the treatment comes in tablet form. Patients have access to multiple options in strengths of 25, 50 and 75mg to suit their requirements.
Tofranil availability in Asia
Tofranil is registered across 14 markets including Malaysia, the Philippines and Indonesia, with availability also in Taiwan, South Korea and Japan. Generic imipramine, much of it made in India, provides a more affordable alternative for expats and residents living far from a nearby pharmacy. Access to such treatments is available to patients across these regions under a doctor’s care.