Thorazine
Intended to address severe psychiatric symptoms by modulating dopaminergic pathways in the brain.
- Category
- Mental Health
- Active ingredient
- Chlorpromazine
- Supply
- Rx
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 50 · 100mg
Thorazine details
- Conditions
- Schizophrenia · Psychotic Disorders · Nausea and Vomiting · Intractable Hiccups
- Alternative names
- Largactil
- Therapeutic class
- Typical Antipsychotic
- Pharmacological class
- Phenothiazine
- Precautions and warnings
- avoid sun and UV exposure; may impair motor coordination
- Minor side effects
- drowsiness; dry mouth; constipation
- Moderate side effects
- dystonia; hypotension; blurred vision
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- GSK
- Onset Time
- 30–60 minutes
- Duration
- 4–6 hours
- Storage instructions
- Store in a light-resistant container at room temperature.
- Drug interactions
- alcohol; sedatives; lithium
- Age restrictions
- Use with extreme caution in geriatric patients.
- Pregnancy and breastfeeding
- Pregnancy: Risk to fetus; consult specialist. Breastfeeding: Not recommended.
Contraindications
hypersensitivity to phenothiazines; central nervous system depression; coma; severe blood dyscrasias
Serious side effects
tardive dyskinesia, requires immediate medical attention; neuroleptic malignant syndrome, requires immediate medical attention
Patient summary
intended to address severe psychiatric symptoms by modulating dopaminergic pathways in the brain.
Mechanism of action
Thorazine acts primarily as an antagonist at postsynaptic dopamine receptors in the limbic system, hypothalamus, and basal ganglia. By blocking these receptors, it reduces the hyperactivity associated with psychotic conditions and helps regain stability in neurotransmitter signaling.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Thorazine
Thorazine is a medication containing chlorpromazine, an active ingredient used to treat schizophrenia, psychotic disorders, and nausea and vomiting. This medication is also sold under the brand name Largactil. It is produced by GSK and is supplied as a tablet in strengths of 50mg and 100mg.
Thorazine availability in Asia
Thorazine is registered across 13 markets, including the Philippines, Indonesia, and Taiwan, with further availability in countries such as South Korea, Japan, and the UAE. While the original brand remains a standard, generic chlorpromazine is often more affordable. For expats and those living in regions where accessing familiar medication can be difficult, this treatment is an option, though it is best used under the ongoing guidance of a doctor.