Nizoral
This treatment is utilized to mitigate severe systemic fungal conditions and designed to address hormone-related pathologies such as cushing's syndrome.
- Category
- Antifungals
- Active ingredient
- Ketoconazole
- Supply
- Pharmacy
- Route
- Oral use
- Form
- Tablet
- Strengths
- 200mg
Nizoral details
- Therapeutic class
- Antifungal
- Pharmacological class
- Imidazole
- Precautions and warnings
- monitor liver function tests; monitor for signs of adrenal insufficiency
- Minor side effects
- nausea; diarrhoea; headache; dizziness
- Moderate side effects
- gynaecomastia; menstrual abnormalities
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- Janssen-Cilag
- Onset Time
- 1–2 weeks
- Duration
- ongoing
- Storage instructions
- Store at room temperature away from moisture.
- Drug interactions
- Alcohol; Antacids; Proton pump inhibitors; Warfarin
- Age restrictions
- Not recommended for children.
Contraindications
hypersensitivity to imidazole; acute or chronic liver disease; concurrent use of cisapride; concurrent use of terfenadine
Serious side effects
hepatotoxicity, requires immediate medical attention; adrenal insufficiency, requires immediate medical attention
Patient summary
This treatment is utilized to mitigate severe systemic fungal conditions and designed to address hormone-related pathologies such as cushing's syndrome.
Mechanism of action
Ketoconazole inhibits the cytochrome P450-dependent synthesis of ergosterol in fungal cell membranes. It also possesses a secondary pharmacological effect of inhibiting adrenal steroid biosynthesis, which is how it is used to manage high cortisol levels.
Pregnancy and breastfeeding
Pregnancy: contraindicated. Breastfeeding: breastfeeding must be discontinued during treatment.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Nizoral
Nizoral is the original antifungal medication containing ketoconazole, which is used for the management of Cushing’s syndrome and severe systemic fungal infections. As a product manufactured by Janssen-Cilag, this treatment is available as a 200mg tablet.
Buying Nizoral online
Nizoral is registered across 14 markets including the Philippines, Indonesia and Taiwan, with additional availability found in South Korea, Japan and the UAE. Generic ketoconazole, much of it made in India, is far more affordable than the original brand, offering an accessible solution for expats and people situated far from a nearby pharmacy. As one of the most ordered products across the region, it is available to order online with delivery throughout many of these locations.