Leukeran
Utilized to manage specific types of blood cancers, formulated to slow the progression of malignant cellular growth in the lymphatic system.
- Category
- Oncology Support
- Active ingredient
- Chlorambucil
- Supply
- Rx
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 2 · 5mg
Leukeran details
- Therapeutic class
- Alkylating Agent
- Pharmacological class
- Nitrogen Mustard Derivative
- Contraindications
- hypersensitivity to chlorambucil; severe bone marrow suppression
- Minor side effects
- nausea; vomiting; diarrhoea
- Moderate side effects
- bone marrow suppression; stomatitis; elevated liver enzymes
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- Aspen Pharma
- Onset Time
- 1–2 weeks
- Duration
- 3–4 weeks
- Storage instructions
- Store in a refrigerator at 2°C to 8°C. Keep in original packaging.
- Drug interactions
- live vaccines
- Age restrictions
- Not recommended for paediatric use.
Precautions and warnings
regular blood monitoring required during treatment; monitor for signs of infection
Serious side effects
secondary malignancies, requires immediate medical attention; interstitial lung disease, requires immediate medical attention; seizures, requires immediate medical attention
Patient summary
Utilized to manage specific types of blood cancers, formulated to slow the progression of malignant cellular growth in the lymphatic system.
Mechanism of action
Chlorambucil is an alkylating agent. It binds to DNA within cells, causing cross-linking that prevents DNA replication and cell division. This process effectively inhibits the proliferation of abnormal, rapidly dividing cancerous cells, particularly those involved in lymphocytic disorders.
Pregnancy and breastfeeding
Pregnancy: must not be used during pregnancy. Breastfeeding: breastfeeding must be discontinued during treatment.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Leukeran
Leukeran is the pharmaceutical brand for Chlorambucil, widely used for the management of Chronic Lymphocytic Leukaemia, Hodgkin Lymphoma and Non-hodgkin Lymphoma. Manufactured by Aspen Pharma, this treatment is supplied as tablets in 2mg and 5mg strengths. It serves as an established therapeutic option for these specific blood-related conditions.
Leukeran availability in Asia
Leukeran is registered across 14 markets including the UAE, Singapore and Hong Kong, with availability also in Thailand, Malaysia and the Philippines. For expats and people living away from major medical centres, knowing where this specific medication is registered can assist in managing ongoing health requirements. Because this is a treatment for serious conditions, it is best used under a doctor’s care.