Alkacel
Formulated to address malignant cell proliferation by supporting the alkylation of DNA and inhibiting cellular replication.
- Category
- Oncology Support
- Active ingredient
- Melphalan
- Supply
- Rx
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 2mg
Alkacel details
- Conditions
- Multiple Myeloma · Ovarian Cancer
- Alternative names
- Alkeran
- Therapeutic class
- Antineoplastic Agent; Alkylating Agent
- Pharmacological class
- Nitrogen Mustard
- Contraindications
- hypersensitivity to melphalan; severe bone marrow suppression
- Minor side effects
- nausea; vomiting; alopecia
- Moderate side effects
- anaemia; leukopenia; thrombocytopenia; stomatitis
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- Celon Laboratories
- Onset Time
- N/A
- Duration
- N/A
- Storage instructions
- Store at 2–8°C.
- Drug interactions
- ciclosporin; nalidixic acid
- Age restrictions
- Use with caution in children.
- Pregnancy and breastfeeding
- Pregnancy: Contraindicated. Breastfeeding: Contraindicated.
Precautions and warnings
regular blood monitoring recommended; avoid conception during treatment; risk of secondary malignancy
Serious side effects
bone marrow failure, requires immediate medical attention; pulmonary fibrosis, requires immediate medical attention
Patient summary
Formulated to address malignant cell proliferation by supporting the alkylation of DNA and inhibiting cellular replication.
Mechanism of action
Melphalan is a bifunctional alkylating agent that creates cross-links in DNA strands, which interferes with DNA replication and transcription, ultimately inducing apoptosis in malignant cells.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Alkacel
Alkacel serves as a treatment containing melphalan, an active ingredient used to manage multiple myeloma and ovarian cancer. Alternative brands for the same medication include Alkeran. Celon Laboratories manufactures this option, which is supplied as a 2mg tablet.
Alkacel availability in Asia
Alkacel is registered across 13 markets including Hong Kong, Thailand and Malaysia, with availability also in the Philippines, Indonesia and Taiwan. Generic melphalan, much of it manufactured in India, often provides a more accessible option compared to the original brand for those seeking consistent treatment while living abroad. Consistent use of such medication is best managed under a doctor’s care to ensure proper monitoring and continuity of therapy.