Cytoxan
Utilized to target malignant neoplasms to alleviate disease progression and cell proliferation.
- Category
- Oncology Support
- Active ingredient
- Cyclophosphamide
- Supply
- Rx
- Route
- Oral use
- Form
- Tablet; Powder for solution for injection
- Strengths
- 50mg
Cytoxan details
- Conditions
- Malignant Lymphoma · Multiple Myeloma · Leukaemia
- Alternative names
- Endoxan
- Therapeutic class
- Alkylating Agent
- Pharmacological class
- Mustard Nitrogen Analogue
- Known off-label uses
- severe rheumatoid arthritis; systemic lupus erythematosus
- Contraindications
- severe bone marrow suppression; hypersensitivity; active infection
- Minor side effects
- nausea; alopecia; fatigue
- Moderate side effects
- cystitis; immunosuppression; infertility
- Dosage forms
- Tablet; Powder for solution for injection
- Administration route
- Oral use
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- Baxter
- Onset Time
- 1–2 weeks
- Duration
- varies by regimen
- Storage instructions
- Store at room temperature, keep dry.
- Drug interactions
- Doxorubicin; Allopurinol
- Age restrictions
- paediatric use requires expert supervision.
Precautions and warnings
maintain adequate hydration; regular blood count monitoring; risk of secondary malignancies
Serious side effects
haemorrhagic cystitis, requires immediate medical attention; bone marrow failure, requires immediate medical attention
Patient summary
Utilized to target malignant neoplasms to alleviate disease progression and cell proliferation.
Mechanism of action
This chemotherapy agent works by cross-linking DNA, which prevents cancer cells from dividing and growing. It is often used as part of combination therapy to manage various types of blood and solid cancers.
Pregnancy and breastfeeding
Pregnancy: Highly teratogenic; must be avoided. Breastfeeding: Absolutely contraindicated; discontinue breastfeeding.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Cytoxan
Cytoxan is a chemotherapy agent containing cyclophosphamide, used in the treatment of conditions including malignant lymphoma, multiple myeloma and leukaemia. The same active ingredient is also available as Endoxan, supplied as 50mg tablets manufactured by Baxter. These medicines are typically managed under the close supervision of a medical specialist to manage side effects and monitor progress.
Cytoxan availability in Asia
Cytoxan is registered across 13 markets, including the UAE, Singapore and Hong Kong, with availability also in Thailand, Malaysia and the Philippines. Generic cyclophosphamide, often made in India, offers a more affordable alternative to the original brand. This accessibility assists expats and individuals living far from specialised care centres with maintaining their regular treatment. Given the nature of this medication, it is best used under a doctor’s care to ensure appropriate treatment monitoring.