Letairis
Developed to target pulmonary hypertension to alleviate respiratory stress.
- Category
- Heart & Blood Pressure
- Active ingredient
- Ambrisentan
- Supply
- Rx
- Route
- Oral use
- Form
- Tablet
- Strengths
- 5 · 10mg
Letairis details
- Condition
- Pulmonary Arterial Hypertension
- Alternative names
- Volibris
- Therapeutic class
- Endothelin Receptor Antagonist
- Pharmacological class
- Endothelin Receptor Antagonist
- Contraindications
- pregnancy; severe hepatic impairment; hypersensitivity to components
- Minor side effects
- headache; nasal congestion; flushing
- Moderate side effects
- peripheral oedema; palpitations; constipation
- Dosage forms
- Tablet
- Administration route
- Oral use
- Patient summary
- developed to target pulmonary hypertension to alleviate respiratory stress.
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- Gilead Sciences
- Onset Time
- 2–4 weeks
- Duration
- Long-term usage
- Storage instructions
- Store at room temperature.
- Drug interactions
- cyclosporine
- Age restrictions
- Adults.
- Pregnancy and breastfeeding
- Pregnancy: Contraindicated (teratogenic). Breastfeeding: Not recommended.
Precautions and warnings
requires liver function monitoring; risk of birth defects; requires consistent contraceptive use in females
Serious side effects
liver failure, requires immediate medical attention; pulmonary oedema, requires immediate medical attention
Mechanism of action
Ambrisentan acts as a selective endothelin receptor antagonist. By blocking the binding of endothelin-1 to receptors in the pulmonary artery walls, it promotes vasodilation and helps manage elevated pressure levels.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Letairis
Letairis is an established brand of ambrisentan, which is used for the management of pulmonary arterial hypertension. The same active ingredient is also available under the brand name Volibris. Produced by Gilead Sciences, these tablets are available in 5mg and 10mg strengths for regular use by those requiring this specific treatment regimen.
Buying Letairis online
Letairis is currently registered across 13 markets, including Japan, the UAE and Singapore, with availability reaching Hong Kong, Thailand and Malaysia. Patients living in these areas often find that ambrisentan, including more affordable generic versions manufactured in India, can be easily ordered online. This helps individuals located far from a well-stocked pharmacy secure their medication with consistent delivery across the region.