Sinemet
Indicated to manage Parkinson's disease, this combination therapy is utilized to support motor function by replacing depleted dopamine in the central nervous system.
Sinemet details
- Condition
- Parkinson's Disease
- Alternative names
- Sinemet Cr
- Therapeutic class
- Dopaminergic Agent
- Pharmacological class
- Decarboxylase Inhibitor/Dopamine Precursor
- Minor side effects
- dyskinesia; nausea; dizziness; dry mouth
- Moderate side effects
- orthostatic hypotension; confusion; insomnia
- Dosage forms
- Tablet; Prolonged-release tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- MSD
- Onset Time
- 30–60 minutes
- Duration
- 3–6 hours
- Storage instructions
- Store below 25°C in original packaging.
- Drug interactions
- antipsychotics; iron supplements; antihypertensives
- Age restrictions
- Not for paediatric use.
- Pregnancy and breastfeeding
- Pregnancy: Not recommended. Breastfeeding: Not recommended.
Contraindications
hypersensitivity to ingredients; narrow-angle glaucoma; concurrent use of non-selective mao inhibitors
Precautions and warnings
may cause sudden sleep onset; monitor for impulse control disorders; periodic haematological monitoring advised
Serious side effects
hallucinations, requires immediate medical attention; neuroleptic malignant syndrome, requires immediate medical attention
Patient summary
Indicated to manage Parkinson's disease, this combination therapy is utilized to support motor function by replacing depleted dopamine in the central nervous system.
Mechanism of action
Levodopa is a precursor to dopamine that crosses the blood-brain barrier. Carbidopa prevents peripheral metabolism of levodopa, increasing the amount available for dopamine conversion in the brain.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Sinemet
Sinemet is the standard treatment for Parkinson’s Disease, containing the active ingredients Carbidopa and Levodopa. The same components are also marketed under the brand Sinemet Cr. These tablets are used to manage symptoms and are available in strengths of 10/100, 25/100 and 25/250mg.
Buying Sinemet online
Sinemet is registered across 14 markets including Malaysia, the Philippines and Indonesia, with availability also in Taiwan, South Korea and Japan. As a staple therapy, it remains one of the most ordered options for expats and residents across the region requiring consistent access. Generic Carbidopa and Levodopa are often available as a more affordable solution than the original MSD brand, making it easier for those living away from local medical suppliers to coordinate delivery across these Asian markets.