Sinemet Cr
Designed to alleviate motor dysfunction in Parkinson's disease through dopamine replenishment.
Sinemet Cr details
- Condition
- Parkinson's Disease
- Alternative names
- Sinemet; Caramet; Duodopa
- Therapeutic class
- Dopamine Precursor / Dopa Decarboxylase Inhibitor
- Pharmacological class
- Dopaminergic Agent
- Minor side effects
- nausea; dizziness; dry mouth
- Moderate side effects
- involuntary movements; confusion; orthostatic hypotension
- Dosage forms
- Modified-release tablet
- Administration route
- Oral use
- Supply category
- Pharmacist only, dispensed without a prescription
- Manufacturer
- MSD
- Onset Time
- 30–90 minutes
- Duration
- 4–6 hours
- Storage instructions
- Store below 25°C, keep container closed.
- Drug interactions
- iron supplements; antipsychotics
- Age restrictions
- Not recommended for children.
- Pregnancy and breastfeeding
- Pregnancy: Consult healthcare professional. Breastfeeding: Avoid administration.
Contraindications
hypersensitivity to components; narrow-angle glaucoma; concurrent use of non-selective maois
Precautions and warnings
may cause sudden sleep onset; monitor for impulse control disorders; avoid rapid discontinuation
Serious side effects
hallucinations, requires immediate medical attention; malignant syndrome, requires immediate medical attention
Patient summary
designed to alleviate motor dysfunction in Parkinson's disease through dopamine replenishment.
Mechanism of action
Sinemet Cr combines levodopa, which crosses the blood-brain barrier to be converted into dopamine, and carbidopa, which prevents periphery metabolism of levodopa. This allows more active substance to reach the brain to improve movement control.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Sinemet Cr
Sinemet Cr combines carbidopa and levodopa for the management of Parkinson’s Disease. This therapeutic formula is also sold under brand names including Sinemet, Caramet and Duodopa. It is supplied as a tablet in a 25/100mg strength and manufactured by MSD.
Buying Sinemet Cr
Sinemet Cr is registered across 13 markets including the Philippines, Indonesia and Taiwan, with availability also in South Korea, Japan and the UAE. Generic carbidopa and levodopa, much of it made in India, provides a far more affordable option compared to the original brand, helping expats and residents secure consistent access to their regular maintenance medication. As one of the most ordered treatments across the region, it is available online with delivery throughout these territories.