Ofev
Developed to target idiopathic pulmonary fibrosis to alleviate breathing difficulties.
- Categories
- Covid-19 Support · Respiratory Health
- Active ingredient
- Nintedanib
- Supply
- Rx
- Route
- Oral use
- Form
- Capsule, soft
- Strengths
- 100mg
Ofev details
- Therapeutic class
- Antifibrotic agent
- Pharmacological class
- Tyrosine kinase inhibitor
- Contraindications
- hypersensitivity to nintedanib; severe hepatic impairment; pregnancy
- Minor side effects
- nausea; diarrhoea; abdominal pain; vomiting; decreased appetite
- Moderate side effects
- elevated liver enzymes; hypertension; weight loss
- Dosage forms
- Capsule, soft
- Administration route
- Oral use
- Supply category
- Prescription only (specially controlled medicine)
- Manufacturer
- Boehringer Ingelheim
- Onset Time
- 1–2 weeks
- Duration
- Ongoing
- Storage instructions
- Store below 25°C in the original blister pack.
- Drug interactions
- P-glycoprotein inhibitors; CYP3A4 inhibitors
- Age restrictions
- Not recommended for children and adolescents under 18 years.
Precautions and warnings
monitor liver function regularly; maintain adequate hydration; avoid cigarette smoking during treatment; use caution with anticoagulant therapy
Serious side effects
haemorrhage, requires immediate medical attention; arterial thromboembolism, requires immediate medical attention; gastrointestinal perforation, requires immediate medical attention
Patient summary
Developed to target idiopathic pulmonary fibrosis to alleviate breathing difficulties.
Mechanism of action
Nintedanib acts as a multiple tyrosine kinase inhibitor. It inhibits pathways involved in fibrosis, preventing the development of scar tissue in the lungs and slowing the decline of lung function.
Pregnancy and breastfeeding
Pregnancy: Use is contraindicated during pregnancy. Breastfeeding: Breastfeeding must be discontinued during treatment.
Where this medicine is registered
- Singapore
- Hong Kong
- Thailand
- Malaysia
- Philippines
- Indonesia
- Taiwan
- South Korea
- Japan
- Australia
- New Zealand
- UAE
- South Africa
About Ofev
Ofev contains nintedanib, a medication used for Idiopathic Pulmonary Fibrosis and Chronic Fibrosing Interstitial Lung Disease. Developed by Boehringer Ingelheim, it is supplied as a 100mg capsule. This treatment offers a targeted approach for individuals with progressive fibrosing lung conditions who require long-term management of their breathing health.
Buying Ofev online
Ofev is registered across 14 markets, including Thailand, Malaysia and the Philippines, with availability also in Indonesia, Taiwan and South Korea. Generic nintedanib, largely produced in India, significantly lowers costs compared to the original brand. This allows expats and residents across the region to secure consistent access to this medication, facilitating care even when without easy access to a pharmacy. It remains one of the most ordered treatments for these specific lung conditions in the region.