Mixed Dyslipidaemia

Mixed dyslipidaemia is a pattern of blood-fat abnormalities in which LDL cholesterol and triglycerides are both elevated, and HDL (“good”) cholesterol is often low. The combination carries a greater cardiovascular risk than any single abnormality alone, and it is particularly prevalent in South and Southeast Asian populations, where genetic tendency towards atherogenic dyslipidaemia interacts with diets high in refined carbohydrates.

Medicines used to treat Mixed Dyslipidaemia

Nexletol

Bempedoic Acid

180mg

Utilized to target hypercholesterolaemia to mitigate cardiovascular risk.

From $1.57 / tablet View

What drives the abnormal lipid pattern

The most common underlying cause is insulin resistance, which simultaneously raises triglyceride production and suppresses HDL. Type 2 diabetes, metabolic syndrome, obesity, heavy alcohol use, and certain thyroid conditions can all produce or worsen the pattern. Family history matters too: familial combined hyperlipidaemia is one of the more frequent inherited causes seen in clinics across India, Malaysia, and the Philippines.

Tackling the full lipid picture

Because mixed dyslipidaemia involves both cholesterol and triglycerides, treatment often goes beyond a single drug class. Fenofibrate is well suited to the triglyceride and HDL component, while agents that target LDL, such as bempedoic acid, address the cholesterol side. Both sit within the broader cholesterol management and heart and blood pressure therapeutic areas. Dietary changes, cutting refined carbohydrates, added sugars, and alcohol, often produce meaningful improvements alongside any medicine.

Persistently high triglycerides (above 10 mmol/L) can trigger pancreatitis; if you experience sudden severe abdominal pain, seek medical attention promptly.