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Chronic Constipation

Chronic constipation is defined as fewer than three bowel movements per week, combined with straining, hard stools, or a persistent sense of incomplete emptying, lasting for at least three months. It is common, and is frequently underreported because many people manage it silently for years before seeking help.

Motegrity

Prucalopride

2mg

Prucalopride 2mg film-coated tablets, used in the management of chronic constipation. A 5-HT4 agonist that stimulates colonic motility.

From$1.56/ tabletView

Key points

  • Two distinct mechanisms drive the condition: the colon can move stool too slowly, or rectal muscles and nerves fail to coordinate during a bowel movement.
  • Low fibre intake, inactivity, poor fluid intake and frequent travel are common contributing factors, alongside certain antacids and pain relievers.
  • When fibre, hydration and routine are not enough, a gut-motility agent such as prucalopride can stimulate coordinated colonic movement.

When the gut stops keeping pace

The condition usually has one of two patterns. In slow-transit constipation the colon moves stool too slowly; in outlet dysfunction the muscles and nerves around the rectum do not co-ordinate properly during a bowel movement. Both can produce the same daily discomfort, bloating, and low-grade fatigue.

Lifestyle factors such as low fibre intake, reduced physical activity, inadequate fluid consumption, and frequent travel all worsen the picture. Certain medicines (including some antacids and pain relievers) can also slow colonic movement as a side effect.

Treatment approaches

For many people, adding soluble fibre, drinking more water, and establishing a regular routine is enough. When those steps fall short, medicines that work directly on gut motility become relevant. Prucalopride is a selective gut-motility agent used for chronic constipation; it targets receptors in the colon to stimulate coordinated movement. More options for gut and bowel conditions are listed in digestive health.

See a doctor if you notice blood in the stool, unexplained weight loss, or a significant change in bowel habit after the age of 50, as these warrant further investigation.

Further reading