Nucala (Mepolizumab) for Eosinophilic Conditions

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How does Nucala (mepolizumab) work?

First approved in 2015 for SEA, Nucala (mepolizumab) is the first-in-class monoclonal antibody that targets IL-5. It is believed to work by preventing IL-5 from binding to its receptor on the surface of eosinophils, reducing blood eosinophils and maintaining them within normal levels.

What is mepolizumab used for?

Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES). It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.

Does Nucala (mepolizumab) treat eosinophilic granulomatosis?

If you have asthma, nasal (nose) polyps, or certain other conditions, your doctor may suggest treatment with Nucala (mepolizumab). It’s a prescription drug that’s used to treat the following conditions: eosinophilic granulomatosis with polyangiitis (also called Churg-Strauss syndrome) in adults

Does Nucala contain mepolizumab?

Nucala contains the active ingredient mepolizumab. (An active ingredient is what makes a drug work.) Nucala is available in three forms, all of which are given as an injection under the skin: Nucala is a biologic medication. Biologics are made using parts of living organisms. Nucala is not available in a biosimilar form.

Can I use Nucala If I am allergic to mepolizumab?

NUCALA is an add-on, prescription maintenance treatment for patients 6 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems. Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA. Do not use to treat sudden breathing problems.

What is Nucala (mepolizumab)?

Nucala (mepolizumab) is a medicine for people ages 6 and older with asthma who continue to have severe asthma attacks despite taking all of their other currently prescribed asthma medicines. It is an add-on maintenance drug, which means that it is taken regularly along with other medicines to help prevent asthma attacks. 1

What is the difference between Nucala 100 mg and mepolizumab 75 mg?

Compared with placebo, patients receiving NUCALA 100 mg or mepolizumab 75 mg IV experienced significantly fewer exacerbations. Additionally, compared with placebo, there were fewer exacerbations requiring hospitalization and/or emergency department visits and exacerbations requiring only in-patient hospitalization with NUCALA 100 mg (Table 4).

What are the side effects of Nucala (mepolizumab)?

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue). Learn more about the relationship between severe eosinophilic asthma, inflammation, and NUCALA (mepolizumab).

What Is Nucala (Mepolizumab)

1. https://www.nucala.com/severe-asthma/about-nucala/why-nucala/
2. https://en.wikipedia.org/wiki/Mepolizumab
3. https://www.drugs.com/nucala.html

Nucala (Mepolizumab) Information

1. https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF
2. https://www.ema.europa.eu/en/medicines/human/EPAR/nucala
3. https://www.medicines.org.uk/emc/product/10563/smpc
4. https://www.nice.org.uk/guidance/ta671/chapter/2-Information-about-mepolizumab
5. https://asthma.net/treatment/nucala