Understanding Oxidative Stress and Its Effects

Imbalance between free radicals and antioxidants, leading to cell and tissue damage.
Application
Cell Biology | Free Radicals | Antioxidants | Cell Damage
Prepared by Lee Cheng, reviewed by Dr. Helena Rodriguez

Oxidative Stress FAQ


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What causes oxidative stress?

Oxidative stress is an imbalance of free radicals and antioxidants in your body that leads to cell damage. It plays a role in many conditions like cancer, Alzheimer’s disease and heart disease. Toxins like pollution and cigarette smoke can cause oxidative stress, while foods rich in antioxidants can help reduce it. What is oxidative stress?

Does oxidative stress matter?

In this case, it does not matter what induces oxidative stress: physical or chemical factors or their combination. It is the result that matters: an increased ROS steady-state level.

Can oxidative stress cause disease?

Oxidative stress can cause damage to many of your tissues, which can lead to a number of diseases over time. While you can’t completely avoid exposure to free radicals, you can make lifestyle choices regarding diet, exercise, and environment to help keep your body in balance, and prevent damage and disease.

Is oxidative distress a stress?

The so defined oxidative distress is an oxidative damage but not an oxidative stress. What is measured and defined as oxidative stress is in fact an oxidative damage.

What causes oxidative stress in disease?

Consequently, a new hypothesis for oxidative stress in disease had to be formulated: Oxidative stress occurs due to alteration of thiol redox circuits, which normally play a role in cellular signaling and physiological regulation [ 5 ].

Which reaction is responsible for oxidative stress?

One reaction responsible for oxidative stress is the lipid peroxidation chain reaction that can be initiated by •OH (reactions 8–10): where LH is a lipid with allylic hydrogens, which are present in polyunsaturated fatty acids including arachidonic acid.

Oxidative Stress References

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