Anti-IgE Therapy - Understanding its Role in Allergy Management

Anti-IgE therapy is a treatment method that involves the use of medications to block the action of IgE antibodies in the body. This therapy is commonly used in the management of allergic conditions.

Anti-IgE Therapy. FAQ

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What is the role of IgE in the treatment of allergic diseases?

Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases.

Does anti-IgE therapy reduce IgE receptor expression on effector cells?

Anti-IgE therapy can reduce IgE receptor expression on effector cells; because IgE is a positive regulator of both FcεRI and FcεRII, reduced IgE results in reduced IgE receptor expression as well [ 20, 21 ].

How is IgE neutralized?

The main method of IgE neutralization being pursued involves achieving specific binding and neutralization of free IgE in serum to prevent it from binding receptors on target cells, thereby inhibiting allergen-induced early/late allergic reactions (Fig. 1 ). Scheme of anti-IgE therapy strategies for IgE-mediated allergic diseases.

What is anti-IgE used for?

Anti-IgE is a form of treatment for allergic conditions that has been approved for the treatment of moderate to severe persistent asthma and chronic idiopathic urticaria (hives with an unknown cause). Anti-IgE interferes with the function of IgE. IgE is an antibody in the immune system. How does anti-IgE work?

What is an ideal IgE inhibitor?

An ideal IgE inhibitor should therefore in addition to neutralizing free IgE, actively disrupt IgE:FcεRI complexes on allergic effector cells and suppress IgE production in B-cells through engagement of either mIgE, CD23-bound IgE or inhibitory co-receptors.

What is the importance of immunoglobulin E (IgE) in atopic disorders?

The importance of immunoglobulin E (IgE) in atopic disorders such as asthma, allergic rhinitis, food allergies, and atopic dermatitis is well established. Elevation of total serum IgE is typically found in many atopic patients, and in predisposed individuals, allergen-specific IgE is produced.