Overview of Immune System Deficiencies

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What is an autoimmune disorder?

In an autoimmune disorder, the immune system attacks the body's own tissues. Sometimes the autoimmune disorder develops before the immunodeficiency causes any symptoms. Primary: These disorders are usually present at birth and are genetic disorders that are usually hereditary. They typically become evident during infancy or childhood.

Why do T-cell disorders cause IG deficiencies?

T-cell disorders also cause Ig deficiencies because the B- and T-cell immune systems are interdependent. Chronic Mucocutaneous Candidiasis Chronic mucocutaneous candidiasis is persistent or recurrent candidal infection due to inherited T-cell defects.

What is a hereditary deficiency?

Hereditary deficiencies are autosomal recessive except for deficiencies of C1 inhibitor, which is autosomal dominant, and properdin, which is X-linked. The deficiencies result in defective opsonization, phagocytosis, and lysis of pathogens and in defective clearance of antigen-antibody complexes.

What are cellular immunodeficiencies (T-cell defects)?

Cellular immunity deficiencies (T-cell defects) account for about 5 to 10% of primary immunodeficiencies and predispose to infection by viruses, Pneumocystis jirovecii , fungi, other opportunistic organisms, and many common pathogens (see table Cellular Immunity Deficiencies ).

What Is Immune System Deficiencies

1. https://www.healthline.com/health/immunodeficiency-disorders
2. https://www.mayoclinic.org/diseases-conditions/primary-immunodeficiency/symptoms-causes/syc-20376905
3. https://www.hopkinsmedicine.org/health/conditions-and-diseases/disorders-of-the-immune-system
4. https://www.webmd.com/a-to-z-guides/immune-deficiency-disorders
5. https://www.merckmanuals.com/home/immune-disorders/immunodeficiency-disorders/overview-of-immunodeficiency-disorders
6. https://en.wikipedia.org/wiki/Immunodeficiency
7. https://my.clevelandclinic.org/health/diseases/17964-primary-immunodeficiency
8. https://www.msdmanuals.com/en-gb/professional/immunology-allergic-disorders/immunodeficiency-disorders/overview-of-immunodeficiency-disorders

Immune System Deficiencies Information

1. https://www.nhsinform.scot/illnesses-and-conditions/immune-system
2. https://www.immunology.org/policy-and-public-affairs/briefings-and-position-statements/immunodeficiency
3. https://www.niaid.nih.gov/diseases-conditions/types-pidds